Chondrocyte apoptosis following intraarticular fracture in humans
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چکیده
منابع مشابه
TNF-α Mediates Diabetes-Enhanced Chondrocyte Apoptosis During Fracture Healing and Stimulates Chondrocyte Apoptosis Through FOXO1
To gain insight into the effect of diabetes on fracture healing, experiments were carried out focusing on chondrocyte apoptosis during the transition from cartilage to bone. Type 1 diabetes was induced in mice by multiple low-dose streptozotocin injections, and simple transverse fractures of the tibia or femur was carried out. Large-scale transcriptional profiling and gene set enrichment analys...
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BACKGROUND Although tibial plateau fracture is an uncommon injury, its regulation is challenging and there are some influencing factors, including the effects of severe bone displacement, depression and cancellous bone cartilage, and inevitable cartilage damage. And GIT1 plays an important role in bone mass and 78 osteoblast cell migration. METHODS The study used 72 C57/BL6 mice. A tibial pla...
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The juxta-articular and intra-articular fracture of distal radius is a common fracture around wrist joint. The treatment by external fixation using the principle of ligamento-taxis by which the longitudinal distraction force is converted to a compressive force to achieve good congruity of the wrist joint. Hence, the present study was taken up to find out the efficacy of the procedure in 116 cas...
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OBJECTIVE To demonstrate posttraumatic chondrocyte apoptosis in the murine xiphoid after a crush-type injury and to ultimately determine the pathway (i.e., intrinsic or extrinsic) by which chondrocytes undergo apoptosis in response to mechanical injury. DESIGN The xiphoids of adult female wild-type mice were injured with the use of a modified Kelly clamp. Postinjury xiphoid cartilage was anal...
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Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is characterized by progressive destruction of articular cartilage, resulting...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2002
ISSN: 1063-4584
DOI: 10.1053/joca.2002.0828